Gene expression changes in blood as a putative biomarker for Huntington's disease
Identifieur interne : 002291 ( Main/Exploration ); précédent : 002290; suivant : 002292Gene expression changes in blood as a putative biomarker for Huntington's disease
Auteurs : Luca Lovrecic [Slovénie] ; Andrej Kastrin [Slovénie] ; Jan Kobal [Slovénie] ; Zvezdan Pirtosek [Slovénie] ; Dimitri Krainc [États-Unis] ; Borut Peterlin [Slovénie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-11-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Artificial Intelligence, Cohort Studies, Female, Gene Expression (physiology), Gene Expression Profiling, Gene expression, Humans, Huntington Disease (blood), Huntington Disease (genetics), Huntington Disease (physiopathology), Huntington disease, Huntington's disease, Male, Middle Aged, Multivariate Analysis, Nervous system diseases, Oligonucleotide Array Sequence Analysis, Parkinson Disease (blood), Parkinson Disease (genetics), Parkinson Disease (physiopathology), RNA, Messenger, Stroke (blood), Trinucleotide Repeat Expansion (genetics), biomarkers, gene expression, neurodegeneration, transcriptomics.
- MESH :
- chemical : RNA, Messenger.
- blood : Huntington Disease, Parkinson Disease, Stroke.
- genetics : Huntington Disease, Parkinson Disease, Trinucleotide Repeat Expansion.
- physiology : Gene Expression.
- physiopathology : Huntington Disease, Parkinson Disease.
- Adult, Artificial Intelligence, Cohort Studies, Female, Gene Expression Profiling, Humans, Male, Middle Aged, Multivariate Analysis, Oligonucleotide Array Sequence Analysis.
Abstract
Several studies demonstrated alterations of gene expression in blood in various neurological disorders including Huntington's disease (HD). Using microarray technology, a recent study identified a large number of significantly altered mRNAs in HD blood, from which a 12‐gene set was selected as classifier for discriminating controls and HD patients. The aim of our study was to validate expression changes of these 12 genes in an independent cohort of HD patients and evaluate their sensitivity and specificity. Four different subject groups were included—patients with HD, Parkinson's disease (PD), acute ischemic stroke (AS) and healthy controls. Although the previous results were successfully validated, gene expression changes in HD blood partly overlapped with those observed in blood from PD and AS patients. Predictive value of the selected biomarker set for HD group was 78%, with 82% sensitivity and 53% specificity. Further gene expression analyses in longitudinal studies are needed to validate and refine possible transcriptomic blood biomarkers in HD. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22477
Affiliations:
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uniqKey="Pirtosek Z" first="Zvezdan" last="Pirtosek">Zvezdan Pirtosek</name><affiliation wicri:level="1"><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Neurology, University Medical Centre, Ljubljana</wicri:regionArea><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Krainc, Dimitri" sort="Krainc, Dimitri" uniqKey="Krainc D" first="Dimitri" last="Krainc">Dimitri Krainc</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Peterlin, Borut" sort="Peterlin, Borut" uniqKey="Peterlin B" first="Borut" last="Peterlin">Borut Peterlin</name><affiliation wicri:level="1"><country 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11-15">2009-11-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2277">2277</biblScope><biblScope unit="page" to="2281">2281</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E8B4EBE2F927120F6EF2A15A0FF26713E3232B6A</idno><idno type="DOI">10.1002/mds.22477</idno><idno type="ArticleID">MDS22477</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Artificial Intelligence</term><term>Cohort Studies</term><term>Female</term><term>Gene Expression (physiology)</term><term>Gene Expression Profiling</term><term>Gene expression</term><term>Humans</term><term>Huntington Disease (blood)</term><term>Huntington Disease (genetics)</term><term>Huntington Disease (physiopathology)</term><term>Huntington disease</term><term>Huntington's disease</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Nervous system diseases</term><term>Oligonucleotide Array Sequence Analysis</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (physiopathology)</term><term>RNA, Messenger</term><term>Stroke (blood)</term><term>Trinucleotide Repeat Expansion (genetics)</term><term>biomarkers</term><term>gene expression</term><term>neurodegeneration</term><term>transcriptomics</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Huntington Disease</term><term>Parkinson Disease</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term><term>Parkinson Disease</term><term>Trinucleotide Repeat Expansion</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Artificial Intelligence</term><term>Cohort Studies</term><term>Female</term><term>Gene Expression Profiling</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Oligonucleotide Array Sequence Analysis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chorée de Huntington</term><term>Expression génique</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies demonstrated alterations of gene expression in blood in various neurological disorders including Huntington's disease (HD). Using microarray technology, a recent study identified a large number of significantly altered mRNAs in HD blood, from which a 12‐gene set was selected as classifier for discriminating controls and HD patients. The aim of our study was to validate expression changes of these 12 genes in an independent cohort of HD patients and evaluate their sensitivity and specificity. Four different subject groups were included—patients with HD, Parkinson's disease (PD), acute ischemic stroke (AS) and healthy controls. Although the previous results were successfully validated, gene expression changes in HD blood partly overlapped with those observed in blood from PD and AS patients. Predictive value of the selected biomarker set for HD group was 78%, with 82% sensitivity and 53% specificity. Further gene expression analyses in longitudinal studies are needed to validate and refine possible transcriptomic blood biomarkers in HD. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Slovénie</li><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="Slovénie"><noRegion><name sortKey="Lovrecic, Luca" sort="Lovrecic, Luca" uniqKey="Lovrecic L" first="Luca" last="Lovrecic">Luca Lovrecic</name></noRegion><name sortKey="Kastrin, Andrej" sort="Kastrin, Andrej" uniqKey="Kastrin A" first="Andrej" last="Kastrin">Andrej Kastrin</name><name sortKey="Kobal, Jan" sort="Kobal, Jan" uniqKey="Kobal J" first="Jan" last="Kobal">Jan Kobal</name><name sortKey="Peterlin, Borut" sort="Peterlin, Borut" uniqKey="Peterlin B" first="Borut" last="Peterlin">Borut Peterlin</name><name sortKey="Pirtosek, Zvezdan" sort="Pirtosek, Zvezdan" uniqKey="Pirtosek Z" first="Zvezdan" last="Pirtosek">Zvezdan Pirtosek</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Krainc, Dimitri" sort="Krainc, Dimitri" uniqKey="Krainc D" first="Dimitri" last="Krainc">Dimitri Krainc</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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